Dr. David Sinclair takes NMN, Resveratrol, Metformin or Berberine, Spermidine, and Glycine as part of his supplement stack.

“Dr. David Sinclair has publicly discussed his supplement regimen in his book, interviews, and on his podcast. Multiple sources from 2024, 2025, and 2026 confirm that his stack includes Nicotinamide Mononucleotide (NMN), Resveratrol, Metformin, and Spermidine. While he has discussed Berberine as a compound of interest, Metformin is the one he consistently states he takes. The claim's inclusion of Glycine is not consistently supported; instead, sources mention he takes Trimethylglycine (TMG), which is related but distinct, to support methylation due to NMN intake. Context: Dr. Sinclair's personal supplement stack has evolved over time and is based on his own research and risk tolerance. He explicitly states that he is not giving medical advice and does not endorse specific brands. The list also includes other substances not mentioned in the claim, such as Vitamin D3, Vitamin K2, and Fisetin.”